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KMID : 0357319930280020105
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Journal of the Korean Society for Microbiology
1993 Volume.28 No. 2 p.105 ~ p.112
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Expression of P, Type 1 Fimbriae, Hep-2 Cell Adherence, and Colonization Factor Antigens of Uropathogenic Escherichia coli
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Abstract
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A total of 88 urine isolates of E. coli from 88 patients who had acute urinary tract infections were examined for their patterns of adherence. The patient's mean age was 28 years (age range, 3/12-72). Seventy percent were women. Of the 88 E. coli
isolates, P fimbriae were present in 10(11%), and type 1 fimbriae were present in 29(33%). P fimbriae was present on 29% of strains causing pyelonephritis, on 17% of strains isolated from cystitis, 0n 7% of asymptomatic bacteriuria, and on 7% of
unclassified urinary tract infections, while type 1 fimbriation was more common (50,67,30 and 36%, respectively, from simillar sources). Of E. coli from patients with pyelonephritis, 7, 21, 7 and 7% expressed diffuse and localized adherence, and
colonization factor antigens I and II. Respectively. We concluded that both P and type 1 fimbriae along with other enteric adherence factors play a synergistic role in upper urinary tract infections in human. No enterohemorrhagic E. coli adhesin
fimbriae was found. The bacterial surface antigen(s) mediating attachment to human urinary tract epithelial cells may be one factor selecting for E. coli from among the fecal flora which infect the urinary tract.
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